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Year Number of Results
2000 1
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2006 5
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2010 3
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2012 2
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2014 3
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2017 2
2019 1
2021 3
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36 results

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Page 1
Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system.
Arora R, Metzger RJ, Papaioannou VE. Arora R, et al. PLoS Genet. 2012;8(8):e1002866. doi: 10.1371/journal.pgen.1002866. Epub 2012 Aug 2. PLoS Genet. 2012. PMID: 22876201 Free PMC article.
Mutants deficient in Tbx4 and Tbx5 show severely reduced lung branching at mid-gestation. Concordant with this defect, the expression of mesenchymal markers Wnt2 and Fgf10, as well as Fgf10 target genes Bmp4 and Spry2, in the epithelium is downregulated. ...F …
Mutants deficient in Tbx4 and Tbx5 show severely reduced lung branching at mid-gestation. Concordant with this defect, the expression …
The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10.
Ng JK, Kawakami Y, Büscher D, Raya A, Itoh T, Koth CM, Rodríguez Esteban C, Rodríguez-León J, Garrity DM, Fishman MC, Izpisúa Belmonte JC. Ng JK, et al. Development. 2002 Nov;129(22):5161-70. doi: 10.1242/dev.129.22.5161. Development. 2002. PMID: 12399308
We find that Tbx5 functions downstream of WNT signaling to regulate Fgf10, which, in turn, maintains Tbx5 expression during limb outgrowth. Furthermore, our results indicate that Tbx5 and Wnt2b function together to initiate and specify forelimb outgrow …
We find that Tbx5 functions downstream of WNT signaling to regulate Fgf10, which, in turn, maintains Tbx5 expression du …
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG. Koshiba-Takeuchi K, et al. Nat Genet. 2006 Feb;38(2):175-83. doi: 10.1038/ng1707. Epub 2005 Dec 25. Nat Genet. 2006. PMID: 16380715
Human mutations in TBX5, a gene encoding a T-box transcription factor, and SALL4, a gene encoding a zinc-finger transcription factor, cause similar upper limb and heart defects. ...Tbx5 and Sall4 interact both positively and negatively to finely regulate patterning …
Human mutations in TBX5, a gene encoding a T-box transcription factor, and SALL4, a gene encoding a zinc-finger transcription factor, …
How the pterosaur got its wings.
Tokita M. Tokita M. Biol Rev Camb Philos Soc. 2015 Nov;90(4):1163-78. doi: 10.1111/brv.12150. Epub 2014 Oct 31. Biol Rev Camb Philos Soc. 2015. PMID: 25361444 Review.
Hoxd11, Hoxd12, and Hoxd13) around the ZPA through pterosaur-specific exploitation of sonic hedgehog (SHH) signalling. 5'Hoxd genes could then influence downstream bone morphogenetic protein (BMP) signalling to facilitate chondrocyte proliferation in long bones. Potential express …
Hoxd11, Hoxd12, and Hoxd13) around the ZPA through pterosaur-specific exploitation of sonic hedgehog (SHH) signalling. 5'Hoxd genes could th …
LMP4 regulates Tbx5 protein subcellular localization and activity.
Camarata T, Bimber B, Kulisz A, Chew TL, Yeung J, Simon HG. Camarata T, et al. J Cell Biol. 2006 Jul 31;174(3):339-48. doi: 10.1083/jcb.200511109. J Cell Biol. 2006. PMID: 16880269 Free PMC article.
Nuclear and cytoplasmic Tbx5 distribution in developing chicken wings suggests the functional significance of the LMP4-Tbx5 interaction. ...To test whether the relocalization from nuclear to cytoplasmic sites interferes with downstream gene expression, we used limb- …
Nuclear and cytoplasmic Tbx5 distribution in developing chicken wings suggests the functional significance of the LMP4-Tbx5 in …
Cardiac regeneration by direct reprogramming in this decade and beyond.
Yamakawa H, Ieda M. Yamakawa H, et al. Inflamm Regen. 2021 Jul 1;41(1):20. doi: 10.1186/s41232-021-00168-5. Inflamm Regen. 2021. PMID: 34193320 Free PMC article. Review.
Myocardial regeneration transdifferentiates cardiac fibroblasts into cardiomyocytes in situ.Three cardiogenic transcription factors: Gata4, Mef2c, and Tbx5 (GMT) can induce direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs), in mice. ...
Myocardial regeneration transdifferentiates cardiac fibroblasts into cardiomyocytes in situ.Three cardiogenic transcription factors: Gata4, …
Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes).
Huynen L, Suzuki T, Ogura T, Watanabe Y, Millar CD, Hofreiter M, Smith C, Mirmoeini S, Lambert DM. Huynen L, et al. BMC Evol Biol. 2014 May 14;14:75. doi: 10.1186/1471-2148-14-75. BMC Evol Biol. 2014. PMID: 24885927 Free PMC article.
Moa Tbx5 is identical to chicken Tbx5 in being able to activate the downstream promotors of fgf10 and ANF. In addition we show that missexpression of moa tbx5 in the hindlimb of chicken embryos results in the formation of forelimb features, suggesting …
Moa Tbx5 is identical to chicken Tbx5 in being able to activate the downstream promotors of fgf10 and ANF. In addition …
RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation.
Nishimoto S, Wilde SM, Wood S, Logan MP. Nishimoto S, et al. Cell Rep. 2015 Aug 4;12(5):879-91. doi: 10.1016/j.celrep.2015.06.068. Epub 2015 Jul 23. Cell Rep. 2015. PMID: 26212321 Free PMC article.
We demonstrate that both pathways are essential and that RA and beta-catenin/TCF/LEF signaling act cooperatively with Hox gene inputs to directly regulate Tbx5 expression. Furthermore, in contrast to previous models, we show that Tbx5 and Tbx4 expression in forelimb …
We demonstrate that both pathways are essential and that RA and beta-catenin/TCF/LEF signaling act cooperatively with Hox gene inputs to dir …
Novel exons in the tbx5 gene locus generate protein isoforms with distinct expression domains and function.
Yamak A, Georges RO, Sheikh-Hassani M, Morin M, Komati H, Nemer M. Yamak A, et al. J Biol Chem. 2015 Mar 13;290(11):6844-56. doi: 10.1074/jbc.M114.634451. Epub 2015 Jan 25. J Biol Chem. 2015. PMID: 25623069 Free PMC article.
TBX5 is the gene mutated in Holt-Oram syndrome, an autosomal dominant disorder with complex heart and limb deformities. ...The finding of new exons in the Tbx5 locus may also be relevant to mutational screening especially in the 30% of Holt-Oram syndrome patients wi …
TBX5 is the gene mutated in Holt-Oram syndrome, an autosomal dominant disorder with complex heart and limb deformities. ...The findin …
Role of Retinoic Acid Signaling, FGF Signaling and Meis Genes in Control of Limb Development.
Berenguer M, Duester G. Berenguer M, et al. Biomolecules. 2021 Jan 9;11(1):80. doi: 10.3390/biom11010080. Biomolecules. 2021. PMID: 33435477 Free PMC article. Review.
With regard to limb initiation, genetic studies demonstrated that activation of FGF10 signaling is required for the emergence of limb buds from the trunk, with Tbx5 and RA signaling acting upstream in the forelimb field, whereas Tbx4 and Pitx1 act upstream in the hi …
With regard to limb initiation, genetic studies demonstrated that activation of FGF10 signaling is required for the emergence of limb …
36 results